2-Amino-4-(trifluoromethyl)benzenethiol → 5-Trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester
反応式
[NH2:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[SH:12].[CH2:13]([O:15][C:16](OCC)([O:22]CC)[C:17](OCC)=O)[CH3:14]>>[CH2:13]([O:15][C:16]([C:17]1[S:12][C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[N:1]=1)=[O:22])[CH3:14]参加物
3
反応条件
- 温度
- 110 °C
実験手順
To 2-amino-4-trifluoromethyl-benzenethiol (0.7 g) was added ethyl triethoxyacetate (3 eq). The mixture was stirred at 110° C. overnight. The reaction mixture was cooled and triturated with hexane. Filtration gave 460 mg of 5-trifluoromethyl-benzothiazole-2-carboxylic acid ethyl ester as a white solid.
後処理
- temperatureThe reaction mixture was cooled
- customtriturated with hexane
- filtrationFiltration
出典と根拠
- ORDレコード
- ord-0b562ebc862241489a596e1f9fcc353b
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07420001B2
反応ノート
読み込み中…