Thionyl Chloride → 5-Bromo-4-isopropoxy-3-methyl-2-chloromethyl-1-benzofuran
反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10]O)=[C:7]([CH3:12])[C:6]=2[C:13]=1[O:14][CH:15]([CH3:17])[CH3:16].S(Cl)([Cl:20])=O>ClCCl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][Cl:20])=[C:7]([CH3:12])[C:6]=2[C:13]=1[O:14][CH:15]([CH3:17])[CH3:16]参加物
4
実験手順
To a solution of (5-bromo-4-isopropoxy-3-methyl-1-benzofuran-2-yl) methanol (0.3 g, 1 mmole) in 10 mL dichloromethane was added 0.73 mL of thionyl chloride and the reaction was stirred at room temperature for 2 hours. The solvent was concentrated in vacuo, the residue was added toluene to provide 0.33 g of 5-bromo-4-isopropoxy-3-methyl-2-chloromethyl-1-benzofuran.
後処理
- concentrationThe solvent was concentrated in vacuo
- additionthe residue was added toluene
出典と根拠
- ORDレコード
- ord-f6afb000054b4925a3dcdffdda2dd3fe
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07420001B2
反応ノート
読み込み中…