Water → 2-(1,1-Dimethylethyl)phenoxypropene

HRID 2953

反応式

HRID 2953 の反応式
[CH2:1](Br)[CH:2]=[CH2:3].[C:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[OH:15])([CH3:8])([CH3:7])[CH3:6].C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O>[CH3:7][C:5]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[O:15][CH:1]=[CH:2][CH3:3])([CH3:8])[CH3:6]

参加物

6

反応物 4

HCID 962WaterHCID 69232-Tert-ButylphenolHCID 7841Allyl bromideHCID 11430Potassium Carbonate

生成物 1

HCID 676312242-(1,1-Dimethylethyl)phenoxypropene

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
35 °C

実験手順

Allyl bromide (69.2 ml), 2-t-butylphenol (122.9 ml) and potassium carbonate (121.6 g) were stirred in 265 ml of acetone at reflux temperature for 50 hours and then cooled to 35° C. Water (600 ml) was added and the resulting layers were separated. The aqueous layer was extracted with 600 ml of diethyl ether. The organic layer was combined with the aqueous layer's ether extract and the resulting solution was dried over sodium sulfate overnight. After sodium sulfate removal, the solvent was evaporated to provide, after further workup, 147 g of the subtitled intermediate.

後処理

  1. temperatureat reflux temperature for 50 hours
  2. customthe resulting layers were separated
  3. extractionThe aqueous layer was extracted with 600 ml of diethyl ether
  4. extractionextract
  5. dry with materialthe resulting solution was dried over sodium sulfate overnight
  6. customAfter sodium sulfate removal
  7. customthe solvent was evaporated
  8. customto provide

出典と根拠

ORDレコード
ord-f43f465340624f4daaa306b11664c6ec
出典データセット
uspto-grants-1998_03
特許番号
US05731336

関連ノート

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