Water → methyl 3-[N'-benzyloxycarbonyl-hydrazinocarbonyl)-benzoate

HRID 29803

反応式

HRID 29803 の反応式
Cl[C:2]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[O:3].[NH:14]([C:16]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:17])[NH2:15].O>C(OCC)C.ClCCl.N1C=CC=CC=1>[CH2:19]([O:18][C:16]([NH:14][NH:15][C:2]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])=[O:3])=[O:17])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

7

反応物 3

HCID 962WaterHCID 79242Benzyl carbazateHCID 15563901Methyl 3-(chlorocarbonyl)benzoate

生成物 1

HCID 12571328methyl 3-[N'-benzyloxycarbonyl-hydrazinocarbonyl)-benzoate

試薬・触媒・溶媒 3

HCID 1049Pyridine溶媒HCID 3283Diethyl Ether溶媒2 回HCID 6344Dichloromethane溶媒

実験手順

10.80 g (54.4 mmol) methyl 3-chlorocarbonyl-benzoate in 100 mL diethyl ether are added dropwise to a solution of 9.04 g (54.4 mmol) benzyl hydrazine carboxylate in 100 mL diethyl ether, 100 mL dichloromethane and 4.83 mL pyridine while cooling with an ice bath. The reaction mixture is stirred overnight at ambient temperature and then combined with water. The precipitated solid is filtered off and washed with diethyl ether. White solid.

後処理

  1. temperaturewhile cooling with an ice bath
  2. filtrationThe precipitated solid is filtered off
  3. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-a1590d231f5e491abba1d3b8bec6d5a0
出典データセット
uspto-grants-2008_09
特許番号
US07423036B2

関連ノート

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