5-Methyl-3-(4-trifluoromethylphenyl)-1H-[1,2,4]triazole → Tert-butyl {1,1-dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propyl}-carbamate

HRID 29810

反応式

HRID 29810 の反応式
[CH3:1][C:2]1[NH:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=2)[N:3]=1.Cl[CH2:18][CH2:19][C:20]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:22])[CH3:21]>>[CH3:22][C:20]([NH:23][C:24](=[O:30])[O:25][C:26]([CH3:29])([CH3:28])[CH3:27])([CH3:21])[CH2:19][CH2:18][N:6]1[C:2]([CH3:1])=[N:3][C:4]([C:7]2[CH:8]=[CH:9][C:10]([C:13]([F:16])([F:14])[F:15])=[CH:11][CH:12]=2)=[N:5]1

参加物

3

反応物 2

HCID 232282615-Methyl-3-(4-trifluoromethylphenyl)-1H-[1,2,4]triazoleHCID 57429079tert-butyl N-(4-chloro-2-methylbutan-2-yl)carbamate

生成物 1

HCID 86607261Tert-butyl {1,1-dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propyl}-carbamate

実験手順

The target compound is obtained analogously to the method described for intermediate product 1c) from 4.90 g (21.6 mmol) 5-methyl-3-(4-trifluoromethyl-phenyl)-1H-[1,2,4]triazol and 7.17 g (32.4 mmol) tert-butyl (3-chloro-1,1-dimethyl-propyl)-carbamate. White solid. Yield: 5.06 g (57%); mass spectroscopy [M+H]+=413.

後処理

  1. customThe target compound is obtained analogously to the method

出典と根拠

ORDレコード
ord-f16bcecf67304ff280fcc11eb5d1c7d1
出典データセット
uspto-grants-2008_09
特許番号
US07423036B2

関連ノート

読み込み中…