Trifluoroacetate → 1,1-Dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propylamine

反応式

[CH3:1][C:2]([NH:22]C(=O)OC(C)(C)C)([CH3:21])[CH2:3][CH2:4][N:5]1[C:9]([CH3:10])=[N:8][C:7]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:6]1.FC(F)(F)C([O-])=O>>[CH3:21][C:2]([NH2:22])([CH3:1])[CH2:3][CH2:4][N:5]1[C:9]([CH3:10])=[N:8][C:7]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([F:20])([F:19])[F:18])=[CH:13][CH:12]=2)=[N:6]1

参加物

反応物 2

HCID 84468Trifluoroacetate

HCID 86607261Tert-butyl {1,1-dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propyl}-carbamate

生成物 1

HCID 597892651,1-Dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propylamine

実験手順

Prepared according to the method described for intermediate product 1d) from tert-butyl {1,1-dimethyl-3-[5-methyl-3-(4-trifluoromethyl-phenyl)-[1,2,4]triazol-1-yl]-propyl}-carbamate. White solid. Yield: 4.72 g (trifluoroacetate); mass spectroscopy [M+H]+=313.

後処理

customPrepared

出典と根拠

ORDレコード: ord-cf6b2bf3d5e743049f754a829033340b
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07423036B2

反応ノート

読み込み中…

参加物