Tetrahydrofuran → 4-(alpha,alpha,alpha-Trifluoro-m-tolyl)imidazo[1,5-a]pyrimidine-8-methanol

反応式

[Al+3:26].[F:1][C:2]([c:3]1[cH:4][c:5](-[c:9]2[cH:10][cH:11][n:12][c:13]3[n:14]2[cH:15][n:16][c:17]3[C:18](=[O:19])[O:20][CH2:21][CH3:22])[cH:6][cH:7][cH:8]1)([F:23])[F:24].[H-:25].[H-:28].[H-:29].[H-:30].[Li+:27].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1>>[F:1][C:2]([c:3]1[cH:4][c:5](-[c:9]2[cH:10][cH:11][n:12][c:13]3[n:14]2[cH:15][n:16][c:17]3[CH2:18][OH:19])[cH:6][cH:7][cH:8]1)([F:23])[F:24]