Methyl 4-(bromomethyl)benzoate → 4-({[2-(4-Chlorophenyl)-6-phenylpyrimidin-4-yl]oxy}methyl)benzoic acid

HRID 29897

反応式

HRID 29897 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([OH:14])[CH:11]=[C:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:9]=2)=[CH:4][CH:3]=1.Br[CH2:22][C:23]1[CH:32]=[CH:31][C:26]([C:27]([O:29]C)=[O:28])=[CH:25][CH:24]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:13]=[C:12]([O:14][CH2:22][C:23]3[CH:32]=[CH:31][C:26]([C:27]([OH:29])=[O:28])=[CH:25][CH:24]=3)[CH:11]=[C:10]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:9]=2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 256687Methyl 4-(bromomethyl)benzoateHCID 178515558HCID 178515558、化合物2 回

生成物 1

HCID 691972484-({[2-(4-Chlorophenyl)-6-phenylpyrimidin-4-yl]oxy}methyl)benzoic acid

実験手順

The title compound was prepared from 2-(4-chloro-phenyl)-6-phenyl-pyrimidin-4-ol (which was obtained in Intermediate 1) and methyl 4-(bromomethyl)benzoate according to Method A and Method B; 1H NMR (DMSO-d6, 300 MHz) δ 5.61 (s, 2H), 7.26 (t, J=9.0 Hz, 2H), 7.45-7.70 (m, 8H), 8.25-8.35 (m, 2H), 8.55 (d, J=6.0 Hz, 2H); LC retention time 3.86 min; MS: m/z (ESI) 415 (M−H).

出典と根拠

ORDレコード
ord-91b7c6a3183541e5a89476a26877f28d
出典データセット
uspto-grants-2008_09
特許番号
US07423044B2

関連ノート

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