Sodium Hydroxide → 7-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine

HRID 30044

反応式

HRID 30044 の反応式
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)=[N:8][N:9]=[C:10]2[NH:13][CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=3)[CH2:16][CH2:15]2)=[CH:5][CH:4]=1.Cl.[NH+]1C=CC=CC=1.[OH-].[Na+]>>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C:7]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[N:8][N:9]=[C:10]2[NH:13][CH:14]2[CH2:15][CH2:16][N:17]([CH2:20][C:21]3[CH:30]=[CH:29][C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=3)[CH2:18][CH2:19]2)=[CH:5][CH:4]=1

参加物

4

反応物 3

HCID 14798Sodium HydroxideHCID 115546837-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine2 回HCID 21584435Pyridinium hydrochloride

生成物 1

HCID 1363949037-Hydroxy-n-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine収率 86.8%

反応条件

温度
210 °C

実験手順

A mixture of 597 mg (1.25 mmol) of 7-methoxy-N-[1-(naphthalen-2-ylmethyl)piperidin-4-yl]-4-phenylphthalazin-1-amine (compound 1) and pyridinium hydrochloride is heated at 210° C. for 45 minutes. The reaction medium is cooled and 1N sodium hydroxide solution is then added. A precipitate forms, which is washed with water and with dichloromethane, and then dried under reduced pressure. 500 mg of a beige-coloured powder are obtained.

後処理

  1. temperatureThe reaction medium is cooled
  2. washA precipitate forms, which is washed with water and with dichloromethane
  3. customdried under reduced pressure

出典と根拠

ORDレコード
ord-e9b7e2235a7a47bfab84ebdfc02c564b
出典データセット
uspto-grants-2008_09
特許番号
US07423030B2

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