Methyl Isocyanate → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamide
反応式
F[C:2](F)(F)C(O)=O.[NH2:8][C:9]1[C:14]([C:15]([C:17]2[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=2[O:24][CH3:25])=[O:16])=[CH:13]N=[C:11]([NH:26][CH:27]2[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]2)[N:10]=1.[CH3:33][N:34]=[C:35]=[O:36]>>[CH3:33][NH:34][C:35]([N:30]1[CH2:31][CH2:32][CH:27]([NH:26][C:11]2[CH:2]=[CH:13][C:14]([C:15](=[O:16])[C:17]3[CH:22]=[C:21]([F:23])[CH:20]=[CH:19][C:18]=3[O:24][CH3:25])=[C:9]([NH2:8])[N:10]=2)[CH2:28][CH2:29]1)=[O:36]参加物
3
実験手順
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and methyl isocyanate (Aldrich, 98%) using the procedure described in Example 24. HRMS, observed: 402.1940, Calcd for (M+H)+: 402.1936.
出典と根拠
- ORDレコード
- ord-679e22877aea40898d3601f9b5da6384