化工社化工社 化学情報印刷レポート · 研究参考用
Pyridine, hydrofluoride (1:1) → (11R,12S,13E,15S)-9-butyryloxy-11,15-dihydroxy-7-thiaprosta-8,13-dienamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine, hydrofluoride (1:1) | HCID 64774 | — |
| 反応物 | (11R,12S,13E,15S)-9-butyryloxy-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienamide | HCID 22883778 | — |
| 生成物 | (11R,12S,13E,15S)-9-butyryloxy-11,15-dihydroxy-7-thiaprosta-8,13-dienamide | HCID 22883781 | 91% |
反応手順
Using as the material and reagent a hydrogen fluoride-pyridine solution (0.2 ml) and (11R,12S,13E,15S)-9-butyryloxy-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienamide (169 mg), the same procedure was followed as in Example 2 to obtain (11R,12S,13E,15S)-9-butyryloxy-11,15-dihydroxy-7-thiaprosta-8,13-dienamide (101 mg, 91%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05731452 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-e7a5f5fa47d44c41aa8f5e9d244fb7f5 |
| 出典メモ | uspto-grants-1998_03 |