Morpholine → 4-((5-Bromopyridin-3-yl)methyl)morpholine

HRID 30471

反応式

HRID 30471 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=O)[CH:5]=[N:6][CH:7]=1.[NH:10]1[CH2:15][CH2:14][O:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[N:6][CH:7]=1

参加物

3

反応物 2

HCID 8083MorpholineHCID 27847345-Bromo-3-pyridinecarboxaldehyde

生成物 1

HCID 223904154-((5-Bromopyridin-3-yl)methyl)morpholine収率 61%

実験手順

The title compound was prepared in a similar way as described in Example 18, Step C, using 5-bromo-pyridine-3-carbaldehyde and morpholine. The crude compound was purified (SiO2: 0-3% 2 M NH3 in MeOH/DCM) to provide the title compound (61%).

後処理

  1. customThe title compound was prepared in a similar way
  2. customThe crude compound was purified (SiO2: 0-3% 2 M NH3 in MeOH/DCM)

出典と根拠

ORDレコード
ord-fa162b65c69e4dc3b185bf027fd7d8b4
出典データセット
uspto-grants-2008_09
特許番号
US07423147B2

関連ノート

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