2-Methoxyethylamine → N-((6-Bromopyridin-2-yl)methyl)-2-methoxyethanamine

HRID 30478ノート

反応式

HRID 30478 の反応式
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[CH3:10][O:11][CH2:12][CH2:13][NH2:14]>>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][NH:14][CH2:13][CH2:12][O:11][CH3:10])[CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 80182-MethoxyethylamineHCID 27570096-Bromopyridine-2-carbaldehyde

生成物 1

HCID 57967278N-((6-Bromopyridin-2-yl)methyl)-2-methoxyethanamine収率 94%

実験手順

The title compound was prepared in a manner similar to that described in Example 18, Step C, using 6-bromo-pyridine-2-carbaldehyde (0.275 g, 1.48 mmol) and 2-methoxy-ethylamine (0.111 g, 1.48 mmol). The crude product was purified (SiO2: 0-5% MeOH/DCM) to yield the title compound (0.34 g, 94%).

後処理

  1. customThe title compound was prepared in a manner similar to
  2. customThe crude product was purified (SiO2: 0-5% MeOH/DCM)

出典と根拠

ORDレコード
ord-96df5a28feab40beb5646f92a9e28476
出典データセット
uspto-grants-2008_09
特許番号
US07423147B2

反応ノート

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