Potassium Carbonate → 3-(N,N-diethylaminopropoxy)butyranilide

HRID 30543

反応式

HRID 30543 の反応式
S([O-])(=O)(=O)C.[CH2:6]([N:8]([CH:11](O)[CH2:12][CH3:13])[CH2:9][CH3:10])[CH3:7].[C:15]([NH:20][C:21]1[CH:22]=[C:23](O)[CH:24]=[CH:25][CH:26]=1)(=[O:19])[CH2:16][CH2:17][CH3:18].C([O-])([O-])=[O:29].[K+].[K+]>CN(C=O)C>[CH2:6]([N:8]([CH2:11][CH2:12][CH2:13][O:29][CH:17]([CH3:18])[CH2:16][C:15]([NH:20][C:21]1[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1)=[O:19])[CH2:9][CH3:10])[CH3:7]

参加物

6

反応物 4

HCID 11430Potassium CarbonateHCID 30688Butyranilide, 3'-hydroxy-HCID 85257MethanesulfonateHCID 5256659Diethylamino-propanol

生成物 1

HCID 684282403-(N,N-diethylaminopropoxy)butyranilide収率 88.9%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The mesylate of N,N-diethylaminopropanol (6 mmol), prepared as described in Example 18 above, was mixed with 3-butyramidophenol (5.0 mmol), and K2CO3 (10 mmol) in anhydrous DMF (10 mL) and the reaction is performed following general procedure B. The crude product is purified using silica gel column chromatography 5% MeOH/DCM as eluent to yield 3-(N,N-diethylaminopropoxy)butyranilide (1.3 g).

後処理

  1. customThe crude product is purified

出典と根拠

ORDレコード
ord-67fb278fb8d946049d25207848a9308e
出典データセット
uspto-grants-2008_09
特許番号
US07423177B2

関連ノート

読み込み中…