Methyl iodide → HCID 11359854、化合物

HRID 3058

反応式

HRID 3058 の反応式
[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([OH:23])=[CH:19][CH:18]=1)[NH:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7].[C:25](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:1][O:2][C:3](=[O:24])[C@H:4]([CH2:16][C:17]1[CH:18]=[CH:19][C:20]([O:23][CH3:25])=[CH:21][CH:22]=1)[NH:5][C:6]([O:8][CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)=[O:7]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 7010613N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester

生成物 1

HCID 11359854HCID 11359854、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

32.94 g (100 mmol) of N-benzyloxycarbonyl-tyrosine methyl ester is mixed in 200 ml of DMF with 27.64 g (200 mmol) of ground potassium carbonate. 15.6 g (110 mmol) of iodomethane is instilled in this suspension and stirred overnight at room temperature. The solution is concentrated by evaporation, dispersed between ethyl acetate and water, and the organic phase is mixed with hexane after drying (Na2SO4). The title compound crystallizes out.

後処理

  1. concentrationThe solution is concentrated by evaporation
  2. additiondispersed between ethyl acetate and water
  3. additionthe organic phase is mixed with hexane
  4. dry with materialafter drying (Na2SO4)
  5. customThe title compound crystallizes out

出典と根拠

ORDレコード
ord-dba6f3dde0664944932faac3af102356
出典データセット
uspto-grants-1998_03
特許番号
US05733522

関連ノート

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