4-Nitrobenzaldehyde → 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione

HRID 30642

反応式

HRID 30642 の反応式
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[S:12]1[CH2:16][C:15](=[O:17])[NH:14][C:13]1=[O:18].N1CCCCC1>C(O)C>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[C:16]2[S:12][C:13](=[O:18])[NH:14][C:15]2=[O:17])=[CH:6][CH:5]=1)([O-:3])=[O:2]

参加物

5

反応物 3

HCID 5414-NitrobenzaldehydeHCID 5437ThiazolidinedioneHCID 8082Piperidine

生成物 1

HCID 27682645-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione収率 59.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-nitrobenzaldehyde (15.1 g), 1,3-thiazolidine-2,4-dione (11.70 g), piperidine (1.70 g) and ethanol (300 mL) was heated under reflux for 24 hrs. The reaction mixture was concentrated. The obtained residue was washed with ethanol to give 5-(4-nitrobenzylidene)-1,3-thiazolidine-2,4-dione as yellow crystals (14.8 g, yield 59%). Recrystallization thereof from acetone-hexane gave pale-yellow prism crystals. melting point: 272-273° C.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 24 hrs
  3. concentrationThe reaction mixture was concentrated
  4. washThe obtained residue was washed with ethanol

出典と根拠

ORDレコード
ord-02854ddf1583494d8386c11c20c29345
出典データセット
uspto-grants-2008_09
特許番号
US07423159B2

関連ノート

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