4-Nitrobenzaldehyde → 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione
反応式
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=O)=[CH:6][CH:5]=1)([O-:3])=[O:2].[S:12]1[CH2:16][C:15](=[O:17])[NH:14][C:13]1=[O:18].N1CCCCC1>C(O)C>[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH:8]=[C:16]2[S:12][C:13](=[O:18])[NH:14][C:15]2=[O:17])=[CH:6][CH:5]=1)([O-:3])=[O:2]参加物
5
実験手順
A mixture of 4-nitrobenzaldehyde (15.1 g), 1,3-thiazolidine-2,4-dione (11.70 g), piperidine (1.70 g) and ethanol (300 mL) was heated under reflux for 24 hrs. The reaction mixture was concentrated. The obtained residue was washed with ethanol to give 5-(4-nitrobenzylidene)-1,3-thiazolidine-2,4-dione as yellow crystals (14.8 g, yield 59%). Recrystallization thereof from acetone-hexane gave pale-yellow prism crystals. melting point: 272-273° C.
後処理
- temperaturewas heated
- temperatureunder reflux for 24 hrs
- concentrationThe reaction mixture was concentrated
- washThe obtained residue was washed with ethanol
出典と根拠
- ORDレコード
- ord-02854ddf1583494d8386c11c20c29345
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07423159B2
反応ノート
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