HCID 69205592、化合物 → 3-(4-Aminobenzyl)-3-pentanol

HRID 30661ノート

反応式

HRID 30661 の反応式
[CH2:1]([C:3]([OH:24])([CH2:22][CH3:23])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11]C(=O)OCC2C=CC=CC=2)=[CH:7][CH:6]=1)[CH3:2]>[C].[Pd].O1CCCC1>[NH2:11][C:8]1[CH:7]=[CH:6][C:5]([CH2:4][C:3]([OH:24])([CH2:1][CH3:2])[CH2:22][CH3:23])=[CH:10][CH:9]=1

参加物

4

反応物 1

HCID 69205592HCID 69205592、化合物

生成物 1

HCID 692088903-(4-Aminobenzyl)-3-pentanol収率 95%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of benzyl 4-(2-ethyl-2-hydroxybutyl)phenylcarbamate (6.30 g), 10% palladium carbon (5.0 g) and tetrahydrofuran (150 mL) was subjected to catalytic reduction under a hydrogen atmosphere at atmospheric pressure. The catalyst was removed by filtration, and the filtrate was concentrated to give 3-(4-aminobenzyl)-3-pentanol as colorless crystals (3.51 g, yield 95%). Recrystallization thereof from ethyl acetate-hexane gave colorless prism crystals. melting point: 85-86° C.

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-7d245f34957b49178ce30191b219e7f3
出典データセット
uspto-grants-2008_09
特許番号
US07423159B2

反応ノート

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