(4-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methanol → HCID 85969110、化合物

HRID 30706ノート

反応式

HRID 30706 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][N:11]([CH3:15])[C:12]=2[CH2:13][OH:14])=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][N:11]([CH3:15])[C:12]=2[CH:13]=[O:14])=[CH:6][CH:7]=1

参加物

4

反応物 1

HCID 69207780(4-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methanol

生成物 1

HCID 85969110HCID 85969110、化合物収率 70%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of [4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]methanol (250 mg), activated manganese dioxide (1.0 g) and tetrahydrofuran (10 ml) was stirred at room temperature for 3 hrs. The reaction mixture was filtered, and the organic layer was concentrated to give 4-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carbaldehyde (172 mg, yield 70%) as pale-yellow crystals.

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe organic layer was concentrated

出典と根拠

ORDレコード
ord-1e93fb7e727246f5890a765717768e33
出典データセット
uspto-grants-2008_09
特許番号
US07423159B2

反応ノート

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