Acetic Acid → 4-Bromo-2-(propan-2-yl)phenol

HRID 30735

反応式

HRID 30735 の反応式
[CH:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10])([CH3:3])[CH3:2].C(O)(=O)C.CS(C)=O.[BrH:19]>O>[Br:19][C:8]1[CH:7]=[CH:6][C:5]([OH:10])=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:9]=1

参加物

6

反応物 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 679Dimethyl SulfoxideHCID 69432-Isopropylphenol

生成物 1

HCID 147934824-Bromo-2-(propan-2-yl)phenol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of 2-isopropylphenol (3.0 g), acetic acid (30 mL) and dimethylsulfoxide (15 mL) was added dropwise 48% hydrobromic acid (15 mL) at room temperature. The mixture was stirred for 30 min, and poured into water. The resulting mixture was extracted with ethyl acetate. The organic layer was washed successively with water, a saturated aqueous solution of sodium bicarbonate and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford the title compound (4.62 g)

後処理

  1. extractionThe resulting mixture was extracted with ethyl acetate
  2. washThe organic layer was washed successively with water
  3. dry with materiala saturated aqueous solution of sodium bicarbonate and brine, and dried over anhydrous magnesium sulfate
  4. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-db39999e8b964026813c5b0fa100f377
出典データセット
uspto-grants-2008_09
特許番号
US07423185B2

関連ノート

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