Tetrahydrofuran → Methyl 4-hydroxy-2-methoxybenzoate

HRID 30740

反応式

HRID 30740 の反応式
C([O:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([O:19][CH3:20])[CH:10]=1)C1C=CC=CC=1.O1CCCC1>CO.[C].[Pd]>[OH:8][C:9]1[CH:18]=[CH:17][C:12]([C:13]([O:15][CH3:16])=[O:14])=[C:11]([O:19][CH3:20])[CH:10]=1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 108260394-Benzyloxy-2-methoxybenzoic acid methyl ester

生成物 1

HCID 12532676Methyl 4-hydroxy-2-methoxybenzoate収率 98%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 887Methanol溶媒

実験手順

To a solution of methyl 4-benzyloxy-2-methoxybenzoate (3.08 g) in methanol (5 mL)/tetrahydrofuran (7.5 mL) was added 10% palladium-carbon (0.3 g) at room temperature under an atmosphere of argon, and the mixture was stirred at that temperature for 2 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to afford the title compound (2.02 g).

後処理

  1. customThe catalyst was removed by filtration
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-cac98ee240c347b09e50e6d4c18e0653
出典データセット
uspto-grants-2008_09
特許番号
US07423185B2

関連ノート

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