Thiophosgene → HCID 178440816、化合物

HRID 30794

反応式

HRID 30794 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([NH2:11])[CH:8]=[CH:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)(O)[O-].[Na+].C(Cl)(Cl)=[S:18]>CC(C)=O>[N-:11]=[C:7]=[S:18].[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 10040ThiophosgeneHCID 793343-tert-ButylanilineHCID 516892Sodium Bicarbonate

生成物 1

HCID 178440816HCID 178440816、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To 3-(tert-butyl)phenylamine in acetone at 0° C. was added sodium bicarbonate (2 eq) and thiophosgene (2 eq). The mixture was brought to ambient temperature and concentrated and partitioned between ethyl acetate and water. The organic layer was dried with sodium bicarbonate and sodium sulfate and concentrated to yield 3-(tert-butyl)benzenisothiocyanate. MS: MH+=192.

後処理

  1. customwas brought to ambient temperature
  2. concentrationconcentrated
  3. custompartitioned between ethyl acetate and water
  4. dry with materialThe organic layer was dried with sodium bicarbonate and sodium sulfate
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-5c2f9b6dcb724652b0a751510608c005
出典データセット
uspto-grants-2008_09
特許番号
US07423150B2

関連ノート

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