Dichloromethane → 1'-(2,2,2-trifluoroacetyl)spiro[indene-1,4'-piperidin]-3(2H)-one

反応式

[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:40][N:41]([c:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1)[CH3:48].[Cl:37][CH2:38][Cl:39].[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[O:8]=[C:9]1[CH2:10][C:11]2([c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]31)[CH2:18][CH2:19][N:20]([C:23]([O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:29])[CH2:21][CH2:22]2>>[F:1][C:2]([C:3](=[O:4])[N:20]1[CH2:19][CH2:18][C:11]2([CH2:10][C:9](=[O:8])[c:17]3[c:12]2[cH:13][cH:14][cH:15][cH:16]3)[CH2:22][CH2:21]1)([F:6])[F:7]