反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][C:11]3[CH:17]=[CH:16][CH:15]=[C:14](C)[C:12]=3[N:13]=2)=[C:4]([F:19])[CH:3]=1.BrC1C=CC(NC2SC3C=C(OC(F)(F)[F:39])C=CC=3N=2)=C(F)C=1.ClC1SC2C=C(F)C=CC=2N=1.FC1C=C(Br)C=CC=1N>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[S:10][C:11]3[CH:17]=[C:16]([F:39])[CH:15]=[CH:14][C:12]=3[N:13]=2)=[C:4]([F:19])[CH:3]=1参加物
5
反応物 4
生成物 1
実験手順
In a similar manner to that described above for the preparation of N-(4-bromo-2-fluorophenyl)-4-methyl-1,3-benzothiazol-2-amine and N-(4-bromo-2-fluorophenyl)-N-(6-trifluoromethoxy-1,3-benzothiazol-2-yl)amine, using 2-chloro-6-fluoro-1,3-benzothiazole and 2-fluoro-4-bromoaniline, was prepared the desired product as a white solid (78% yield). 1H NMR (400 MHz, DMSO-d6) δ 10.50 (s, 1H), 8.60 (t, 1H), 7.80 (d, 1H), 7.60 (m, 2H), 7.40 (d, 1H), 7.20 (m, 1H).
出典と根拠
- ORDレコード
- ord-fb12bb7feef047119a0c927a4f97ec34
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07423156B2
関連ノート
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