2-(5-Ethynyl-4-hydroxyamino-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol → 2-(4-Hydroxyamino-5-vinyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

HRID 30965ノート

反応式

HRID 30965 の反応式
[C:1]([C:3]1[C:11]2[C:10]([NH:12][OH:13])=[N:9][CH:8]=[N:7][C:6]=2[N:5]([CH:14]2[C:18]([CH3:20])([OH:19])[CH:17]([OH:21])[CH:16]([CH2:22][OH:23])[O:15]2)[CH:4]=1)#[CH:2].[H][H]>C1COCC1.[Pd].CC([O-])=O.CC([O-])=O.[Pb+2]>[OH:13][NH:12][C:10]1[C:11]2[C:3]([CH:1]=[CH2:2])=[CH:4][N:5]([CH:14]3[C:18]([CH3:20])([OH:19])[CH:17]([OH:21])[CH:16]([CH2:22][OH:23])[O:15]3)[C:6]=2[N:7]=[CH:8][N:9]=1

参加物

5

反応物 2

HCID 210408352-(5-Ethynyl-4-hydroxyamino-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 210408282-(4-Hydroxyamino-5-vinyl-pyrrolo[2,3-d]pyrimidin-7-yl)-5-hydroxymethyl-3-methyl-tetrahydro-furan-3,4-diol

試薬・触媒・溶媒 2

HCID 131709914Lindlars catalyst触媒HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound from Example 29 is dissolved in THF and placed under hydrogen (1 atm) in the presence of Lindlar's catalyst until one mole of hydrogen is consumed.

後処理

  1. customis consumed

出典と根拠

ORDレコード
ord-f9c19a0ec1e048cab0e3cb38330568f2
出典データセット
uspto-grants-2008_09
特許番号
US07425547B2

反応ノート

読み込み中…