L-Lactic Acid → (s)-2-Hydroxy-n-[(s)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl]-propionamide

HRID 31020

反応式

HRID 31020 の反応式
[NH2:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2.[C:22](O)(=[O:26])[C@H:23]([CH3:25])[OH:24]>>[OH:24][C@@H:23]([CH3:25])[C:22]([NH:1][C@@H:2]1[C:8](=[O:9])[N:7]([CH2:10][CH2:11][O:12][CH3:13])[C:6]2[CH:14]=[CH:15][CH:16]=[CH:17][C:5]=2[C:4]2[CH:18]=[CH:19][CH:20]=[CH:21][C:3]1=2)=[O:26]

参加物

3

反応物 2

HCID 107689L-Lactic AcidHCID 58972510(S)-7-Amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one

生成物 1

HCID 58972513(s)-2-Hydroxy-n-[(s)-5-(2-methoxy-ethyl)-6-oxo-6,7-dihydro-5h-dibenzo[b,d]azepin-7-yl]-propionamide

実験手順

Using (S)-7-amino-5-(2-methoxy-ethyl)-5H,7H-dibenzo[b,d]azepin-6-one and L-(+)-lactic acid, the title compound was prepared in the same manner as described for example 5a. Colourless, viscous oil (>98%). MS: m/e=355(M+H+).

出典と根拠

ORDレコード
ord-50f42e7a695f4fd2adf0489fbc11d8ea
出典データセット
uspto-grants-2008_09
特許番号
US07425551B2

関連ノート

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