Hydrogen Bromide → 1,2-Dihydro-4-[4-(dimethylaminomethyl)phenyl]-5-hydroxy-1-oxoisoquinoline hydrobromide
反応式
[CH3:1][N:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[OH:21])[C:14](=[O:22])[NH:13][CH:12]=2)=[CH:7][CH:6]=1)[CH3:3].[BrH:23]>CO>[BrH:23].[CH3:3][N:2]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[CH:18][C:19]=3[OH:21])[C:14](=[O:22])[NH:13][CH:12]=2)=[CH:9][CH:10]=1)[CH3:1]参加物
4
実験手順
To a suspension of the compound of Example 1 (200 mg, 679 μmol) in methanol (10 mL) was used 1 mol/L hydrobromic acid (679 μL, 679 μmol), and, through the process similar to Example 121, 250 mg of the title compound were afforded as light brown powder. Yield 97%.
出典と根拠
- ORDレコード
- ord-9eafabbab21d454e8b249be1e2a03e96
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425563B2
反応ノート
読み込み中…