2-Methoxy-6-nitrobenzoic acid → 2-Amino-6-methoxybenzoic Acid

HRID 3112ノート

反応式

HRID 3112 の反応式
[CH3:1][O:2][C:3]1[C:8]([C:9]([OH:11])=[O:10])=[C:7]([N+:12]([O-])=O)[CH:6]=[CH:5][CH:4]=1>C(O)C.[Pd]>[NH2:12][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[C:9]([OH:11])=[O:10]

参加物

4

反応物 1

HCID 133000352-Methoxy-6-nitrobenzoic acid

生成物 1

HCID 27353572-Amino-6-methoxybenzoic Acid収率 100.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 6-methoxy-2-nitrobenzoic acid (3.25 g, 16.5 mM) in ethanol (180 mL) containing 10% palladium-on-carbon catalyst (0.30g) was hydrogenated using a Parr apparatus. When hydrogen consumption ceased, the resulting mixture was filtered through diatomaceous earth and the filtrate concentrated to provide the title benzoic acid (2.76 g, 100%) as a tan solid; MS(CI): 168 (M+H).

後処理

  1. customWhen hydrogen consumption
  2. filtrationthe resulting mixture was filtered through diatomaceous earth
  3. concentrationthe filtrate concentrated

出典と根拠

ORDレコード
ord-49d860bfec704ababf3ed788e3799c62
出典データセット
uspto-grants-1998_03
特許番号
US05733910

反応ノート

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