Water → 4-(9-cyclopentyl-7,7-difluoro-6-oxo-5-propyl-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(1-methyl-piperidin-4-yl)-benzamide

HRID 311848

反応式

[CH3:53][CH:54]([OH:55])[CH3:56].[Cl:1][c:2]1[n:3][cH:4][c:5]2[c:6]([n:23]1)[N:7]([CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1)[CH2:8][C:9]([F:16])([F:17])[C:10](=[O:15])[N:11]2[CH2:12][CH2:13][CH3:14].[NH2:24][c:25]1[cH:26][cH:27][c:28]([C:29](=[O:30])[NH:31][CH:32]2[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]2)[cH:39][cH:40]1.[OH2:41].[c:42]1([CH3:43])[cH:44][cH:45][c:46]([S:47]([OH:48])(=[O:49])=[O:50])[cH:51][cH:52]1>>[c:2]1([NH:24][c:25]2[cH:26][cH:27][c:28]([C:29](=[O:30])[NH:31][CH:32]3[CH2:33][CH2:34][N:35]([CH3:38])[CH2:36][CH2:37]3)[cH:39][cH:40]2)[n:3][cH:4][c:5]2[c:6]([n:23]1)[N:7]([CH:18]1[CH2:19][CH2:20][CH2:21][CH2:22]1)[CH2:8][C:9]([F:16])([F:17])[C:10](=[O:15])[N:11]2[CH2:12][CH2:13][CH3:14]