Tetrahydrofuran → 4-Chloro-3-methoxyaniline

HRID 31356

反応式

HRID 31356 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][C:3]=1[O:11][CH3:12].C1COCC1>[Ni].CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[CH:4][C:3]=1[O:11][CH3:12]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 705192-Chloro-5-nitroanisole

生成物 1

HCID 131036924-Chloro-3-methoxyaniline収率 92.6%

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A mixture of 36 g of 2-chloro-5-nitroanisole and Raney nickel® in 150 ml of MeOH and 200 ml of THF is hydrogenated in Parr apparatus for 4 hours, at 35° C. and under a pressure of 1.3 bar. The catalyst is filtered off over Celite® and the filtrate is concentrated under vacuum. 28 g of the expected product are obtained and are used without further purification.

後処理

  1. filtrationThe catalyst is filtered off over Celite®
  2. concentrationthe filtrate is concentrated under vacuum

出典と根拠

ORDレコード
ord-a77733feb375483f93c36535d0ed4529
出典データセット
uspto-grants-2008_09
特許番号
US07425566B2

関連ノート

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