Water → 4-Chloro-5-methyl-1H-indole-2,3-dione

HRID 31357ノート

反応式

HRID 31357 の反応式
[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[CH:4](SC)[C:5](=[O:12])[NH:6]2.ClN1C(=[O:21])CCC1=O.C1COCC1.O>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[C:10]([CH3:11])=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:21])[C:5](=[O:12])[NH:6]2

参加物

6

反応物 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 31398ChlorosuccinimideHCID 219059304-Chloro-5-methyl-3-(methylthio)indolin-2-one

生成物 1

HCID 225608594-Chloro-5-methyl-1H-indole-2,3-dione収率 80.9%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

This compound is prepared according to the procedure described in step B of Preparation 1.23, starting with 0.72 g of 4-chloro-5-methyl-3-methylthio-1,3-dihydro-2H-indol-2-one and 0.422 g of N-chlorosuccinimide in 72 ml of carbon tetrachloride, and then 58 ml of THF and 14 ml of water. The product obtained is chromatographed on silica gel, eluting with DCM and then with a gradient of a DCM/EtOAc mixture up to (90/10; v/v). 0.5 g of the expected product is obtained.

後処理

  1. customThis compound is prepared
  2. customdescribed in step B of Preparation 1.23
  3. customThe product obtained
  4. customis chromatographed on silica gel
  5. washeluting with DCM

出典と根拠

ORDレコード
ord-a3e00b97b8384adb9e456ce4da6926c6
出典データセット
uspto-grants-2008_09
特許番号
US07425566B2

反応ノート

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