Ethanol → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid
反応式
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:16]CC)=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2].[OH-].[Na+].C(O)C>O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2]参加物
5
実験手順
A solution of 1.55 g of ethyl 1-isopropyl-2(1H)-quinolone-3-carboxylate and 0.28 g of sodium hydroxide in a solvent mixture of 10 ml of ethanol and 2 ml of water was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, and after addition of dil. hydrochloric acid, the precipitated solid was collected by filtration, washed with water and dried to give 1.22 g of 1-isopropyl-2(1H)-quinolone-3-carboxylic acid. m.p. 168°-169° C. (ethyl acetate)
後処理
- customThe solvent was evaporated under reduced pressure
- additionafter addition of dil. hydrochloric acid
- filtrationthe precipitated solid was collected by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-0fb4566f15574ed1bc3456297724c43f
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733917
反応ノート
読み込み中…