Ethanol → 1-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid

HRID 3145

反応式

HRID 3145 の反応式
[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([O:16]CC)=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2].[OH-].[Na+].C(O)C>O>[CH:1]([N:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[C:6]([C:14]([OH:16])=[O:15])[C:5]1=[O:19])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 15468682Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate

生成物 1

HCID 109442901-Isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylic acid収率 88.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of 1.55 g of ethyl 1-isopropyl-2(1H)-quinolone-3-carboxylate and 0.28 g of sodium hydroxide in a solvent mixture of 10 ml of ethanol and 2 ml of water was stirred at room temperature overnight. The solvent was evaporated under reduced pressure, and after addition of dil. hydrochloric acid, the precipitated solid was collected by filtration, washed with water and dried to give 1.22 g of 1-isopropyl-2(1H)-quinolone-3-carboxylic acid. m.p. 168°-169° C. (ethyl acetate)

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. additionafter addition of dil. hydrochloric acid
  3. filtrationthe precipitated solid was collected by filtration
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-0fb4566f15574ed1bc3456297724c43f
出典データセット
uspto-grants-1998_03
特許番号
US05733917

関連ノート

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