1-Bromo-2-Chloroethane → 1-(3-Bromophenyl)cyclopropane-1-carbonitrile

HRID 31497

反応式

HRID 31497 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][C:6]#[N:7].Br[CH2:12][CH2:13]Cl.[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2([C:6]#[N:7])[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1

参加物

6

反応物 3

HCID 78491-Bromo-2-ChloroethaneHCID 14798Sodium HydroxideHCID 36023(3-Bromophenyl)acetonitrile

生成物 1

HCID 200261781-(3-Bromophenyl)cyclopropane-1-carbonitrile

試薬・触媒・溶媒 2

HCID 66133Benzyl triethylammonium chloride触媒HCID 962Water溶媒

実験手順

25 g (0.13 mol) of 3-bromo-benzylcyanide are taken up in 32 ml (0.38 mol) of 1-bromo-2-chloro-ethane and combined with 0.6 g (2.6 mmol) of benzyltriethylammonium chloride. Then a solution of 105.8 g (2.65 mol) of sodium hydroxide in 106 ml of water is added dropwise at 10 to 25° C. After 20 hours at 55° C. the reaction solution is poured onto ice water and extracted with ethyl acetate. The organic extracts are dried and evaporated down. The residue is triturated with petroleum ether, suction filtered and dried.

後処理

  1. additionAfter 20 hours at 55° C. the reaction solution is poured onto ice water
  2. extractionextracted with ethyl acetate
  3. customThe organic extracts are dried
  4. customevaporated down
  5. customThe residue is triturated with petroleum ether, suction
  6. filtrationfiltered
  7. customdried

出典と根拠

ORDレコード
ord-b3bcfc84b2f1474e97d064fd72e6f4ff
出典データセット
uspto-grants-2008_09
特許番号
US07425641B2

関連ノート

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