1-Bromo-2-Chloroethane → 1-(3-Bromophenyl)cyclopropane-1-carbonitrile
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[CH2:5][C:6]#[N:7].Br[CH2:12][CH2:13]Cl.[OH-].[Na+]>[Cl-].C([N+](CC)(CC)CC)C1C=CC=CC=1.O>[Br:1][C:2]1[CH:3]=[C:4]([C:5]2([C:6]#[N:7])[CH2:13][CH2:12]2)[CH:8]=[CH:9][CH:10]=1参加物
6
実験手順
25 g (0.13 mol) of 3-bromo-benzylcyanide are taken up in 32 ml (0.38 mol) of 1-bromo-2-chloro-ethane and combined with 0.6 g (2.6 mmol) of benzyltriethylammonium chloride. Then a solution of 105.8 g (2.65 mol) of sodium hydroxide in 106 ml of water is added dropwise at 10 to 25° C. After 20 hours at 55° C. the reaction solution is poured onto ice water and extracted with ethyl acetate. The organic extracts are dried and evaporated down. The residue is triturated with petroleum ether, suction filtered and dried.
後処理
- additionAfter 20 hours at 55° C. the reaction solution is poured onto ice water
- extractionextracted with ethyl acetate
- customThe organic extracts are dried
- customevaporated down
- customThe residue is triturated with petroleum ether, suction
- filtrationfiltered
- customdried
出典と根拠
- ORDレコード
- ord-b3bcfc84b2f1474e97d064fd72e6f4ff
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425641B2
反応ノート
読み込み中…