Water → HCID 59792850、化合物

HRID 31554ノート

反応式

HRID 31554 の反応式
[Si]([O:8][CH2:9][C@@H:10]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[CH2:25][N:26]2[CH:30]=[CH:29][CH:28]=[C:27]2[C:31](=[O:39])[C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)=[CH:19][CH:18]=1)[C:11]([O:13][CH3:14])=[O:12])(C(C)(C)C)(C)C.O>C1COCC1>[OH:8][CH2:9][C@@H:10]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[CH2:25][N:26]2[CH:30]=[CH:29][CH:28]=[C:27]2[C:31](=[O:39])[C:32]2[CH:37]=[CH:36][C:35]([CH3:38])=[CH:34][CH:33]=2)=[CH:19][CH:18]=1)[C:11]([O:13][CH3:14])=[O:12]

参加物

4

反応物 2

HCID 962WaterHCID 59792879Methyl (2r)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-[(4-{(1e)-3-[2-(4-methylbenzoyl)-1h-pyrrol-1-yl]prop-1-en-1-yl}benzyl)oxy]propionate

生成物 1

HCID 59792850HCID 59792850、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The compound of Example 68-4 (260 mg, 0.48 mmol) was dissolved in THF (5 ml), and thereto was added n-tetrabutylammonium fluoride (1 mol/liter in THF) (1.5 ml, 0.72 mmol) under ice-cooling. Under ice-cooling, the mixture was stirred for one hour, and thereto was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated saline, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound.

後処理

  1. temperaturecooling
  2. temperatureUnder ice-cooling
  3. extractionthe mixture was extracted with ethyl acetate
  4. washThe organic layer was washed with water and saturated saline
  5. dry with materialdried over anhydrous magnesium sulfate
  6. customThe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3c346d18f4f5487bbe9a2d98913b04a4
出典データセット
uspto-grants-2008_09
特許番号
US07425642B2

反応ノート

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