Neopentyl glycol → 2-((Benzyloxy)methyl)-5,5-dimethyl-1,3-dioxane

HRID 31565

反応式

HRID 31565 の反応式
[CH2:1]([O:8][CH2:9][CH:10]=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:12][C:13]([CH3:18])([CH2:16]O)[CH2:14][OH:15]>O.C1(C)C=CC(S(O)(=O)=O)=CC=1.C1(C)C=CC=CC=1>[CH2:1]([O:8][CH2:9][CH:10]1[O:15][CH2:14][C:13]([CH3:18])([CH3:16])[CH2:12][O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 2

HCID 31344Neopentyl glycolHCID 108989(Phenylmethoxy)acetaldehyde

生成物 1

HCID 597925572-((Benzyloxy)methyl)-5,5-dimethyl-1,3-dioxane収率 96.6%

試薬・触媒・溶媒 2

HCID 521998p-Toluenesulfonic acid monohydrate触媒HCID 1140Toluene溶媒

実験手順

To a mixture of benzyloxyacetaldehyde (5 g, 33.3 mmol), 2,2-dimethyl-1,3-propanediol (4.16 g, 40 mmol) and toluene (70 ml), p-toluenesulfonic acid monohydrate (287 mg, 1.51 mmol) was added and refluxed for 4 hours while removing water by the Dean-Stark apparatus. After the reaction mixture was cooled to room temperature, triethylamine (4 ml) was added to the reaction mixture and the solvent was removed by evaporation. The residue was purified by silica gel column chromatography (silica gel: 200 g, elution solvent: ethyl acetate/heptane=1/9) to obtain the title compound (7.6 g, yield: 96.6%) as a colorless oil.

後処理

  1. additionwas added
  2. temperaturerefluxed for 4 hours
  3. customwhile removing water by the Dean-Stark apparatus
  4. additiontriethylamine (4 ml) was added to the reaction mixture
  5. customthe solvent was removed by evaporation
  6. customThe residue was purified by silica gel column chromatography (silica gel: 200 g, elution solvent: ethyl acetate/heptane=1/9)

出典と根拠

ORDレコード
ord-95876f928d594ffb87130057875b8aae
出典データセット
uspto-grants-2008_09
特許番号
US07425634B2

関連ノート

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