Dimethylformamide → 1-Acetoxy-2-butanone

HRID 31656

反応式

HRID 31656 の反応式
Br[CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[C:7]([O-:10])(=[O:9])[CH3:8].[K+].CN(C)C=O>O>[C:7]([O:10][CH2:2][C:3](=[O:6])[CH2:4][CH3:5])(=[O:9])[CH3:8]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 131561-Bromo-2-butanoneHCID 517044Potassium Acetate

生成物 1

HCID 153021-Acetoxy-2-butanone収率 95.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 1-bromobutan-2-one (10 g, 66.2 mmol), potassium acetate (7.8 g, 79.4 mmol), and N,N-dimethylformamide (50 ml) was stirred at room temperature for 5 days. Water was added to the reaction mixture and extracted with diethyl ether twice. The organic layers were combined and washed with a saturated saline solution, dried over magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to obtain the title compound (8.24 g) in the form of a mixture with N,N-dimethylformamide.

後処理

  1. extractionextracted with diethyl ether twice
  2. washwashed with a saturated saline solution
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltrated
  5. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-049619a60e2141dfa110ff7f51c64d80
出典データセット
uspto-grants-2008_09
特許番号
US07425634B2

関連ノート

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