Dimethylformamide → 1-Acetoxy-2-butanone
反応式
Br[CH2:2][C:3](=[O:6])[CH2:4][CH3:5].[C:7]([O-:10])(=[O:9])[CH3:8].[K+].CN(C)C=O>O>[C:7]([O:10][CH2:2][C:3](=[O:6])[CH2:4][CH3:5])(=[O:9])[CH3:8]参加物
5
実験手順
A mixture of 1-bromobutan-2-one (10 g, 66.2 mmol), potassium acetate (7.8 g, 79.4 mmol), and N,N-dimethylformamide (50 ml) was stirred at room temperature for 5 days. Water was added to the reaction mixture and extracted with diethyl ether twice. The organic layers were combined and washed with a saturated saline solution, dried over magnesium sulfate, and filtrated. The filtrate was concentrated under reduced pressure to obtain the title compound (8.24 g) in the form of a mixture with N,N-dimethylformamide.
後処理
- extractionextracted with diethyl ether twice
- washwashed with a saturated saline solution
- dry with materialdried over magnesium sulfate
- filtrationfiltrated
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-049619a60e2141dfa110ff7f51c64d80
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425634B2
反応ノート
読み込み中…