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4-Chloro-2,3,5-trimethyl-1-oxidopyridin-1-ium → 2-(((4-((2-(Fluoromethyl)-1,3-dioxan-2-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Chloro-2,3,5-trimethyl-1-oxidopyridin-1-ium | HCID 2779141 | — |
| 反応物 | (2-(Fluoromethyl)-1,3-dioxan-2-yl)methanol | HCID 59792600 | — |
| 反応物 | 2-(((4-((5,5-Dimethyl-1,3-dioxan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776588 | — |
| 生成物 | 2-(((4-((2-(Fluoromethyl)-1,3-dioxan-2-yl)methoxy)-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776537 | 12% |
反応手順
The same procedure as in the steps (1c) to (1g) of Example 1 was repeated using 4-chloro-2,3,5-trimethylpyridine 1-oxide and (2-(fluoromethyl)-1,3-dioxan-2-yl)methanol to obtain the title compound (331 mg, 5 steps: 12%) as a yellow solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425634B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-8355213a781d4266a970f4324bc79970 |
| 出典メモ | uspto-grants-2008_09 |