1,4-Benzodioxane-2-methanol → 2-(((4-(2,3-Dihydro-1,4-benzodioxin-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 31682

反応式

HRID 31682 の反応式
[Na:1].[CH3:2][C:3]1[C:4]([CH2:21][S:22]([C:24]2[NH:28][C:27]3[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=3[N:25]=2)=[O:23])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][CH2:11][C:12]1(CCC)OC[CH2:15][CH2:14][O:13]1.OCC1O[C:39]2[CH:41]=[CH:42]C=C[C:38]=2[O:37]C1>>[Na:1].[O:37]1[C:38]2[CH:39]=[CH:41][CH:42]=[CH:15][C:14]=2[O:13][CH2:12][CH:11]1[CH2:10][O:9][C:8]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:21][S:22]([C:24]2[NH:28][C:27]3[CH:29]=[CH:30][CH:31]=[CH:32][C:26]=3[N:25]=2)=[O:23])[C:3]=1[CH3:2]

参加物

3

反応物 2

HCID 193141,4-Benzodioxane-2-methanolHCID 667766942-(((3-Methyl-4-(2-(2-propyl-1,3-dioxan-2-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

生成物 1

HCID 667762752-(((4-(2,3-Dihydro-1,4-benzodioxin-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt収率 3%

実験手順

The same procedure as in the steps (8c) to (8g) of Example 8 was repeated using 2-hydroxymethyl-1,4-benzodioxane to obtain the title compound (141 mg, total yield: 3%) as a white solid.

出典と根拠

ORDレコード
ord-461e9c9428284904b53b2453491a6152
出典データセット
uspto-grants-2008_09
特許番号
US07425634B2

関連ノート

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