Trifluoroacetic acid → Trifluoroacetic acid

HRID 32082ノート

反応式

HRID 32082 の反応式
C(OC(=O)[NH:7][CH:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([CH2:18][N:19]3[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]3)[CH:14]=2)[CH2:9]1)(C)(C)C.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]>C(Cl)Cl>[N:19]1([CH2:18][C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][CH:8]([NH2:7])[CH2:17][CH2:16]3)[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24]1.[C:26]([OH:32])([C:28]([F:31])([F:30])[F:29])=[O:27]

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 59486432HCID 59486432、化合物

生成物 2

HCID 6422Trifluoroacetic acidHCID 59486397HCID 59486397、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(6-Piperidin-1-ylmethyl-1,2,3,4-tetrahydro-naphthalen-2-yl)-carbamic acid tert-butyl ester (Step E) (0.113 g, 0.327 mmol) was suspended in CH2Cl2 (2.5 mL) then TFA was added (2.5 mL). The reaction was stirred at RT until complete consumption of starting material was observed by HPLC analysis (2 h). The reaction mixture was concentrated in vacuo to afford the crude title compound as the bis-TFA salt, which was used without further purification. MS (APCI pos) 245 (M+H).

後処理

  1. customwas observed by HPLC analysis (2 h)
  2. concentrationThe reaction mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-86d1c68262054a1786359a55d7cc21fa
出典データセット
uspto-grants-2008_09
特許番号
US07425631B2

反応ノート

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