2-[(Dimethylamino)methylidene]cyclohexane-1,3-dione → 2-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one

HRID 32127

反応式

HRID 32127 の反応式
[C:1]([Si:5]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[O:6][CH2:7][CH2:8][C:9]([NH2:11])=[NH:10])([CH3:4])([CH3:3])[CH3:2].CN([CH:27]=[C:28]1[C:33](=[O:34])[CH2:32][CH2:31][CH2:30][C:29]1=O)C>CCO>[C:1]([Si:5]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[O:6][CH2:7][CH2:8][C:9]1[N:11]=[CH:27][C:28]2[C:33](=[O:34])[CH2:32][CH2:31][CH2:30][C:29]=2[N:10]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 3593532-[(Dimethylamino)methylidene]cyclohexane-1,3-dioneHCID 588414073-(Tert-butyldiphenylsilyloxy)propanamidine

生成物 1

HCID 588413472-(2-(tert-butyldiphenylsilyloxy)ethyl)-7,8-dihydroquinazolin-5(6H)-one

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 3-(tert-butyl-diphenyl-silanyloxy)-propionamidine (25 g, 77 mmol) and 2-dimethylaminomethylene-cyclohexane-1,3-dione (12.8 g, 77 mmol) in 400 mL of dry EtOH was heated at 80° C. for 3 h. After cooling to RT, the solvent was evaporated. Flash chromatography (SiO2, EtOAc/hexane=1:1) gave the desired compound as a white solid.

後処理

  1. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-1934d873284f448895a79663ca6cef26
出典データセット
uspto-grants-2008_09
特許番号
US07425631B2

関連ノート

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