Hydrochloric Acid → HCID 178418386、化合物

HRID 321976

反応式

HRID 321976 の反応式
[O:1]=[C:2]([CH2:8][C:9](=[O:19])[C:10]1[C:15]([CH3:16])=[CH:14][C:13]([CH3:17])=[CH:12][C:11]=1[CH3:18])[C:3]([O:5][CH2:6][CH3:7])=[O:4].Cl.[N:21]([O-])=[O:22].[Na+]>C(O)C>[O:1]=[C:2]([C:8](=[N:21][OH:22])[C:9](=[O:19])[C:10]1[C:11]([CH3:18])=[CH:12][C:13]([CH3:17])=[CH:14][C:15]=1[CH3:16])[C:3]([O:5][CH2:6][CH3:7])=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14945000Ethyl 2,4-dioxo-4-(2,4,6-trimethylphenyl)butanoateHCID 23668193Sodium Nitrite

生成物 1

HCID 178418386HCID 178418386、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

N2O3 gas was slowly passed into a stirred solution of the product of step A (16.2 g) in 300 mL of ethanol until the disappearance of starting material was confirmed by TLC. N2O3 gas was generated by the dropwise addition of 12N aqueous HCl solution into an aqueous slurry of NaNO2. The solvent was removed from the mixture and 200 mL of water was added to the residue. The product was then extracted into ether. The ether extract was dried over Na2SO4 and evaporated to give 16.1 g of a semi-solid.

後処理

  1. customThe solvent was removed from the mixture and 200 mL of water
  2. additionwas added to the residue
  3. extractionThe product was then extracted into ether
  4. extractionThe ether extract
  5. dry with materialwas dried over Na2SO4
  6. customevaporated

出典と根拠

ORDレコード
ord-2c0368633ec242138ca06c698cd783de
出典データセット
uspto-grants-2001_04
特許番号
US06211187B1

関連ノート

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