Phenacyl bromide → 2-(2-Bromophenoxy)-1-phenylethan-1-one
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12].C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12]参加物
5
実験手順
To a solution of 2-bromophenol (8.71 g; 50.3 mmol) and bromoacetophenone (10.1 g; 50.5 mmol) in 50 ml acetone was added K2CO3 (7.02 g; 50.8 mmol). The mixture was heated to reflux for 10 h, cooled to r.t., filtered, diluted with EtOAc (100 ml), washed with HCl (1.0 M, 2×100 ml) and brine, dried over MgSO4 and concentrated. The residual solid was recrystallized from EtOAc:hexane to afford the desired material.
後処理
- temperatureThe mixture was heated
- temperatureto reflux for 10 h
- filtrationfiltered
- additiondiluted with EtOAc (100 ml)
- washwashed with HCl (1.0 M, 2×100 ml) and brine
- dry with materialdried over MgSO4
- concentrationconcentrated
- customThe residual solid was recrystallized from EtOAc
出典と根拠
- ORDレコード
- ord-e8ea565d4667442bad8a8029ce85b129
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211197B1
反応ノート
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