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Toluene → 2-Benzyloxy-6-bromopyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Toluene | HCID 1140 | — |
| 反応物 | 2,6-Dibromopyridine | HCID 12274 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 触媒 | 18-Crown-6 | HCID 28557 | — |
| 生成物 | 2-Benzyloxy-6-bromopyridine | HCID 817475 | — |
反応手順
A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06211220B1 |
| 出典データセット | uspto-grants-2001_04 |
| ORD ID | ord-93682894d27b42bb9ad767ec95113533 |
| 出典メモ | uspto-grants-2001_04 |