反应详情

A stirred mixture of 2,6-dibromopyridine (3.55 g), benzyl. alcohol (1.63 g), potassium hydroxide (1.68 g), 18-Crown-6 (0.20 g) and toluene (25 ml) is heated under reflux for 30 minutes. The cool solution washed with water and brine, dried (MgSO4) and evaporated to give an oil which is vacuum-distilled (Kugelrohr) to give 3.85 g of 2-benzyloxy-6-bromopyridine, bp 220-225° C./1.0 mm.

1. temperatureunder reflux for 30 minutes
2. washThe cool solution washed with water and brine
3. dry with materialdried (MgSO4)
4. customevaporated
5. customto give an oil which
6. distillationis vacuum-distilled (Kugelrohr)