(4-(Ethylamino)-2-(methylthio)pyrimidin-5-yl)methanol → 4-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde

HRID 3221

反応式

HRID 3221 の反応式
[CH2:1]([NH:3][C:4]1[C:9]([CH2:10][OH:11])=[CH:8][N:7]=[C:6]([S:12][CH3:13])[N:5]=1)[CH3:2]>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[CH2:1]([NH:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][N:7]=[C:6]([S:12][CH3:13])[N:5]=1)[CH3:2]

参加物

4

反応物 1

HCID 10584149(4-(Ethylamino)-2-(methylthio)pyrimidin-5-yl)methanol

生成物 1

HCID 107504444-(Ethylamino)-2-(methylthio)pyrimidine-5-carbaldehyde収率 97.8%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒2 回HCID 6212Chloroform溶媒

実験手順

To 4-ethylamino-2-methylthio-5-pyrimidinemethanol (6.44 g, 32.4 mmol) in 600 mL of chloroform was added manganese oxide (21.0 g, 241 mmol) over 3 minutes. The suspension was stirred at room temperature for 2 hours, and an additional 5.5 g of manganese oxide was added. Stirring was continued for 4.5 hours. The mixture was then filtered through celite washing with chloroform. The filtrate was concentrated in vacuo to give 6.25 g (97%) of 4-ethylamino-2-methylthio-5-formylpyrimidine; mp 58°-61° C.

後処理

  1. stirringStirring
  2. waitwas continued for 4.5 hours
  3. filtrationThe mixture was then filtered
  4. washthrough celite washing with chloroform
  5. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-0f80dab124bd4936956f14f0363292fa
出典データセット
uspto-grants-1998_03
特許番号
US05733914

関連ノート

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