1,3-Dichloroacetone → 4-Chloromethyl-2-(3,5-dimethoxyphenyl)oxazole

反応式

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[C:10]([O:12][CH3:13])[CH:11]=1)[C:6]([NH2:8])=[O:7].[Cl:14][CH2:15][C:16]([CH2:18]Cl)=O>>[Cl:14][CH2:15][C:16]1[N:8]=[C:6]([C:5]2[CH:9]=[C:10]([O:12][CH3:13])[CH:11]=[C:3]([O:2][CH3:1])[CH:4]=2)[O:7][CH:18]=1

参加物

反応物 2

HCID 107931,3-Dichloroacetone

HCID 728783,5-Dimethoxybenzamide

生成物 1

HCID 220097284-Chloromethyl-2-(3,5-dimethoxyphenyl)oxazole収率 59%

実験手順

In substantially the same manner as in Reference Example 31, 3,5-dimethoxybenzamide was allowed to react with 1,3-dichloroacetone to give 4-chloromethyl-2-(3,5-dimethoxyphenyl)oxazole. The yield was 59%. Recrystallization from ethyl acetate-hexane gave colorless needles, mp 85-86° C.

出典と根拠

ORDレコード: ord-1e068f773ee24b4ebacd0233d74729f9
出典データセット: uspto-grants-2001_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06211215B1

反応ノート

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