1,3-Dichloroacetone → 2-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole

HRID 322287ノート

反応式

HRID 322287 の反応式
[Br:1][C:2]1[S:6][C:5]([C:7]([NH2:9])=[O:8])=[CH:4][C:3]=1[CH3:10].[Cl:11][CH2:12][C:13]([CH2:15]Cl)=O>>[Br:1][C:2]1[S:6][C:5]([C:7]2[O:8][CH:15]=[C:13]([CH2:12][Cl:11])[N:9]=2)=[CH:4][C:3]=1[CH3:10]

参加物

3

反応物 2

HCID 107931,3-DichloroacetoneHCID 220096685-Bromo-4-methylthiophene-2-carboxamide

生成物 1

HCID 220097082-(5-Bromo-4-methyl-2-thienyl)-4-chloromethyloxazole収率 53%

実験手順

In substantially the same manner as in Reference Example 47, 5-bromo-4-methyl-2-thiophenecarboxamide was allowed to react with 1,3-dichloroacetone to give 2-(5-bromo-4-methyl-2-thienyl)-4-chloromethyloxazole. The yield was 53%. Recrystallization from ethyl acetate-hexane gave clolorless prisms, mp 71-72° C.

出典と根拠

ORDレコード
ord-ee9cbf52665b4d95b55b26e7429ee636
出典データセット
uspto-grants-2001_04
特許番号
US06211215B1

反応ノート

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