(4-Ethylamino-2-phenylamino-pyrimidin-5-yl)methanol → 4-Ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde
反応式
[CH2:1]([NH:3][C:4]1[C:9]([CH2:10][OH:11])=[CH:8][N:7]=[C:6]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]=1)[CH3:2]>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[CH2:1]([NH:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][N:7]=[C:6]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]=1)[CH3:2]参加物
4
実験手順
To a solution of (4-ethylamino-2-phenylamino-pyrimidin-5-yl)methanol (173 mg, 0.71 mmol) in 15 mL of chloroform was added manganese oxide (600 mg, 6.89 mmol). After stirring at room temperature overnight, the mixture was filtered through a pad of Celite, washing with chloroform. The filtrate was concentrated in vacuo to give 170 mg (99%) of 4-ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde; mp 155°-157° C.
後処理
- filtrationthe mixture was filtered through a pad of Celite
- washwashing with chloroform
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-01090b6109b34cf4ad06377fa270ba3b
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733914
反応ノート
読み込み中…