(4-Ethylamino-2-phenylamino-pyrimidin-5-yl)methanol → 4-Ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde

HRID 3223

反応式

HRID 3223 の反応式
[CH2:1]([NH:3][C:4]1[C:9]([CH2:10][OH:11])=[CH:8][N:7]=[C:6]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]=1)[CH3:2]>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[CH2:1]([NH:3][C:4]1[C:9]([CH:10]=[O:11])=[CH:8][N:7]=[C:6]([NH:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:5]=1)[CH3:2]

参加物

4

反応物 1

HCID 10681743(4-Ethylamino-2-phenylamino-pyrimidin-5-yl)methanol

生成物 1

HCID 108240804-Ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde収率 99%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒HCID 6212Chloroform溶媒

実験手順

To a solution of (4-ethylamino-2-phenylamino-pyrimidin-5-yl)methanol (173 mg, 0.71 mmol) in 15 mL of chloroform was added manganese oxide (600 mg, 6.89 mmol). After stirring at room temperature overnight, the mixture was filtered through a pad of Celite, washing with chloroform. The filtrate was concentrated in vacuo to give 170 mg (99%) of 4-ethylamino-2-phenylamino-pyrimidine-5-carbaldehyde; mp 155°-157° C.

後処理

  1. filtrationthe mixture was filtered through a pad of Celite
  2. washwashing with chloroform
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-01090b6109b34cf4ad06377fa270ba3b
出典データセット
uspto-grants-1998_03
特許番号
US05733914

関連ノート

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