1,3-Dichloroacetone → 4-Chloromethyl-2-(5-cyano-2-thienyl)oxazole
反応式
[C:1]([C:3]1[S:7][C:6]([C:8]([NH2:10])=[O:9])=[CH:5][CH:4]=1)#[N:2].[Cl:11][CH2:12][C:13]([CH2:15]Cl)=O>>[Cl:11][CH2:12][C:13]1[N:10]=[C:8]([C:6]2[S:7][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[O:9][CH:15]=1参加物
3
実験手順
In substantially the same manner as in Reference Example 47, 5-cyano-2-thiophenecarboxamide was reacted with 1,3-dichloroacetone to obtain 4-chloromethyl-2-(5-cyano-2-thienyl)oxazole. The yield was 22%. Recrystallization from ethyl acetate-hexane gave colorless prisms, mp 146-147° C.
出典と根拠
- ORDレコード
- ord-24fec3037f8f47a7810991f9bbb98d4c
- 出典データセット
- uspto-grants-2001_04
- 特許番号
- US06211215B1
反応ノート
読み込み中…