3-(4-Methoxybenzylamino)-5-chloro-6-methyl-1-benzyloxycarbonylmethyl-pyrazinone → 3-(4-Methoxybenzylamino)-5-chloro-6-methyl-1-carboxymethylpyrazinone
反応式
[CH3:1][O:2][C:3]1[CH:30]=[CH:29][C:6]([CH2:7][NH:8][C:9]2[C:10](=[O:28])[N:11]([CH2:17][C:18]([O:20]CC3C=CC=CC=3)=[O:19])[C:12]([CH3:16])=[C:13]([Cl:15])[N:14]=2)=[CH:5][CH:4]=1>C1(C)C=CC=CC=1.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][NH:8][C:9]2[C:10](=[O:28])[N:11]([CH2:17][C:18]([OH:20])=[O:19])[C:12]([CH3:16])=[C:13]([Cl:15])[N:14]=2)=[CH:29][CH:30]=1参加物
4
実験手順
A solution of the benzyl ester 18-4 (1.06 g, 2.48 mmol) in toluene (60 mL) was degassed with argon and then 150 mg 10% palladium on carbon was added. The mixture was stirred under an atmosphere of hydrogen gas for 16 h. The solution was filtered through celite and the solvent evaporated to give the title compound 18-5 as a white solid: