3-(4-Methoxybenzylamino)-6-methyl-1-carboxymethyl pyrazinone → (3-Amino-6-methyl-2-oxopyrazin-1(2H)-YL)acetic acid

HRID 322547ノート

反応式

HRID 322547 の反応式
COC1C=CC(C[NH:8][C:9]2[C:10](=[O:20])[N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:12]([CH3:15])=[CH:13][N:14]=2)=CC=1>FC(F)(F)C(O)=O>[NH2:8][C:9]1[C:10](=[O:20])[N:11]([CH2:16][C:17]([OH:19])=[O:18])[C:12]([CH3:15])=[CH:13][N:14]=1

参加物

3

反応物 1

HCID 220087443-(4-Methoxybenzylamino)-6-methyl-1-carboxymethyl pyrazinone

生成物 1

HCID 22008747(3-Amino-6-methyl-2-oxopyrazin-1(2H)-YL)acetic acid

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

The pyrazinone 18-6 (900 mg) was heated at reflux in trifluoroacetic acid (20 mL) for 7 h. The volatiles were removed in vacuo and the residue was azeotroped with CH2Cl2, then EtOAc then MeOH. MeOH was added to the residue and the solution filtered to remove impurities. Removal of the methanol then afforded the title compound 18-7 which was used as such:

後処理

  1. customThe volatiles were removed in vacuo
  2. customthe residue was azeotroped with CH2Cl2
  3. additionMeOH was added to the residue
  4. filtrationthe solution filtered
  5. customto remove impurities
  6. customRemoval of the methanol

出典と根拠

ORDレコード
ord-8b4d4be21f104dcea21508ba435f4df0
出典データセット
uspto-grants-2001_04
特許番号
US06211184B1

反応ノート

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